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  4. Warning signs include emotional outbursts, withdrawal, and seeing or hearing things that arent real. Drug Interactions Hydrochlorothiazide Drugs that alter gastrointestinal motility : The bioavailability of thiazide-type diuretics may be increased by anticholinergic agents (e.g., atropine, biperiden apparently due to propranolol vs carvedilol a decrease in gastrointestinal motility and the stomach propranolol vs carvedilol emptying rate.